Zones is an option Or you can specify a different audio device (or renderer) in the Video option as per snapshot attached.
And for audio Under Audio option I use another device (ASIO USB Dac). Don't forget to check bitsreaming if you want AC3/DTS audio going to a Dolby Digital or DTS capable receiver.
What I like about this VS Zone is it's totally tranparent to the user ie no user intervention required bwn audio and video files. But I also use zones if I want to show Video display while listening to music in the background.
So you don't have to run 2 different MC instances separately. This works great. Sky is the limit