Most lossless formats are within about 5% of each other as far as compression is concerned.
How fast it is to compress/decompress can vary quite a bit though.
FLAC/ALAC are the most popular formats because they have good metadata support, and wide hardware support.
I use ALAC because I have a number of Apple devices, and this allows me to copy/stream files on to them without conversion.
Really, that is all that matters—they all sound the same.
As for hybrid lossless/lossy formats, I actually dislike this. I want the format I am using to only support lossless audio.
