Yes, it shows up fine in WMP10. It does not show up in MC11. I get a "No Handheld Available" message. And, it does not show up in the drive tree either. I get my Karma icon in the system tray so I know that Windows is recognizing it. And, I have no problems with it in Rio's Software.
I did notice that if I connect my Karma while MC is running, I get a flashing message in the Action Window that says "Device Connected" but when I go to Handheld it says nothing is connected.
Media Center Registered 11.0.140 -- c:\Program Files\J River\Media Center 11\
Microsoft Windows XP Workstation 5.1 Service Pack 2 (Build 2600)
AMD Athlon 1848 MHz MMX / Memory: Total - 719 MB, Free - 374 MB
Internet Explorer: 6.0.2900.2180 / ComCtl32.dll: 5.82 (xpsp_sp2_rtm.040803-2158) / Shlwapi.dll: 6.00.2900.2180 (xpsp_sp2_rtm.040803-2158) / Shell32.dll: 6.00.2900.2180 (xpsp_sp2_rtm.040803-2158) / wnaspi32.dll: N/A
Ripping / Drive E: TOSHIBA DVD-ROM SD-R2212 Mode:Normal Type:Auto Speed:Max
Digital playback: Yes / Use YADB: Yes / Get cover art: No / Calc replay gain: Yes / Copy volume: 32767
Eject after ripping: No / Play sound after ripping: No
Burning / Drive E: TOSHIBA DVD-ROM SD-R2212 Addr: 1:0:0 Speed:16 MaxSpeed:16 BurnProof:Yes
Test mode: No / Eject after writing: Yes / Direct decoding: Yes / Write CD-Text: No
Use playback settings: No / Normalization: None