I'm interested in this too.
The Harmony remotes look neat, but they don't control a computer nicely.
The Gyration MCE remote looks kind of neat, but I use a keyboard often.
That tiny clam-shell Logitech keyboard looks slick, but I'm scared it'd take me an hour to type an email with it.
Years ago, I had a wireless Belkin keyboard with integrated mouse that could control IR components like the TV and stereo. It was a great idea because it pulled everything I needed together. It had kludgy control of IR components, and I always wished they'd come out with another generation. They didn't.
The Microsoft Remote (keyboard + mouse + IR) has bad reviews for the mouse and the IR is limited.
Are there other options that provide IR, mouse, and keyboard?