Yep. This is what Zones are for.
MC can even link them and you can play the same thing to both simultaneously. The sync is usually pretty good, though not good enough for playing in the same room (within clear ear-shot of each other), with most audio devices. Because USB DACs have their own buffering schemes, however, keeping these in sync can be challenging.
Still though, with most music, for a "whole house audio" setup (each DAC or audio device drives a different room), it works quite well.