I have been experiencing this problem probably since I started using Media Center (around v20.0.87). Sometimes when selecting a smartlist (definitely does happen) or a library view (not so sure, I tried it several times now and it's not happening, but I could swear it used to) the first song in the list gets highlighted. It gets in the way if automatic shuffle is used.
Also sometimes when selecting a smartlist or a library view it would only get ''half-selected''. When this happens a smartlist or a library view would get highlighted by a lighter shade of yellow (aruba skin) as opposed to deep yellow. What happens when a tree item is ''half-selected'' is that I can see all the songs associated with that smartlist or view and playback will start if play button is pressed, but said tree item can't be renamed or deleted - when right clicking those options are greyed out.