Yes you do need the driver software on one machine. As has been said, that allows you to search for channels, update firmware and also use the capability with other tv software even programs like VLC.
Once done MC will find the tuners and you can go through the normal tv set up within MC. I find the HDHomerun kit a really neat and effective solution, so much better than adding cards or USB tuners and with the benefit of having tv available to phones and tablets on your network.
One thing I have found is that a high quality and strong signal is required, so if you have issues such as pixellation then the aerial is the first place to look. There is android software HDHomerun Signal meter available to check it via Google play store.