frankly I find this to be way too much work
That's how i feel about makemkv.
Is there any reason not to use iso for DVDs and skip makemkv?
ISO means the file has to be mounted to a virtual drive and you have to deal with menus/adverts.
Menus and adverts shouldn't be a problem, but there is no reason to mount an iso when you can just rip to hard disc and play that.
Is there any known fix for the problem playing dvd movies from large usb drives?
Maybe you can split the 4tb drive into 2 partitions so you are only dealing with 2 TB drives. Just an idea.
I used 3TB external drives with dvd rips for a couples years without ever having a problem.
My thoughts on DVD and Blu-ray rips:
Don't use iso's.
Don't use makemkv.
Simply rip to hard disc folder. MC is perfect for it.
I don't think any other media player handles rips as nicely.
They import as a single file that can be tagged and played back just like the disc was being played.
Playing adds is a non-issue because blu-ray goes straight to the main title and with DVD's you just right click and choose "DVD Menu" to skip adds.
I personally like seeing adds because it's the only time I see trailers.
I have MC setup to tag on import so ripping and importing is very fast.
It takes 5 minutes or so to rip a dvd and less than a minute to rename and move the folder.
Auto Import and Tag on Import take care of the rest.
I buy a lot of box sets with 30 - 60 discs and couldn't imagine converting each disc.
While movies are simple to deal with, TV show rips can be a little more complicated.
I tag my discs with multiple episodes like so: Season 1 Episode 1-3, Season 1 Episode 4-6.
It works well except for discs that have no order and span multiple seasons. With those I use "random" as the episode.
Particles can be used to split up, tag, and scrape individual episodes on rips but I haven't had the time to do too much of my own.
There is lots of info around on how to use particles.
I suggest spending a couple hours trying out MC's features before spending countless hours converting.