I'm running Plex Media Server (PMS) & MC side by side on the same HTPC and there are zero issues. they use different ports so there's no conflict. I use MC for all my mp3 organization & for streaming music since its by far more superior at the music than anything on the market. I use PMS for streaming my movie collection around the house and any where I want to see a movie. Plex is far superior than MC with transcoding and movie organization and the client apps available and the GUI interface leaves MC in the dust. if MC could show some love to the Media Center part of their app which includes the 10ft tall GUI for big screen viewing, along with major rework of the gui on the client side, I would consider using jrmc as my one stop shop media center app. I discovered a long time ago that there's no single software that does it all well, when it comes to media center applications despite all the functions being there. I pick the best of breed for each type of media, MC for music, Plex for movies, & Google Photos for pics. hell even my Synology NAS has better photos & movie apps.