Your screenshots suggest that you're trying to change resampling while audio is playing (at the top it says "processing", and you've got an audio level in the lower left hand corner). That won't work well. Try stopping playback entirely (not pause) before making any changes in DSP studio's output format block. MC won't typically let you change sampling rates on DACs during playback of a single track.
If that's not it, I've encountered a similar issue when I'm using the same device for global output (with pulse) and then trying to use hardware direct outputs in MC. The issue is that pulseaudio sometimes grabs the device and doesn't release it again, locking the sample rate to 48KHz, and then when MC tries to play to the device it either errors or offers to try a working format (which resamples to 48KHz). Sometimes MC will automatically try a working format depending on your settings.
Try making sure that your system default sound device is set to a different device than the USB DAC, and then see if you can make the "no change" settings stick. If so, you're seeing the same issue I saw. If not you've got a different problem.