I have a 3x16 GB RAID5 with Toshiba MG08ACA16TE drives and I'm very happy with them. It's true they are in an always-on NAS, 20.000 power-on hours with just 5 power cycles so far. I believe they would do just fine on a non-NAS setting too, but I have no data on that. The r/DataHoarder forum is a really good place to ask about this:
https://www.reddit.com/r/DataHoarder/Helium-filled drives tend to always have the same standby noise level at the same capacity - it just depends on the number of platters inside them (density), which is similar for any given disk size across brands. Actuator noise is much more annoying and brand-specific - I find I really dislike the WD and Seagate head-moving noises, it can be extremely clicky.
Avoid cheap SMR drives (shingled magnetic recording), must be CMR. I think most drives at these higher capacities are CMR, after the last WD fiasco that resulted in a class action lawsuit...
Assuming you want to do RAID:
- with 2x22TB you'll have a RAID1 with 22 TB available capacity; 1 disk can fail without data loss
- with 3x16TB you'll have a RAID5 with 32 TB available capacity; 1 disk can fail without data loss
If not using RAID (why?), then I'd go for fewer drives - less heat, less noise.