If you really want to know a lot about networks, you'll have to go digging on the Internet (and not on audiophile forums).
Like computers, networks are extremely reliable, but there are lots of bad things that can happen to them, so it's not possible to generalize in any useful way.
If you're asking about whether a network likes to move big chunks or little ones, the answer is no. It doesn't care. Small chunks have more overhead, but at network speeds, it just doesn't matter.
Remember a 10Mb network? That's really old, but it still moves 10 million bits per second, or (adding some for overhead) about 1 million bytes per second. A 3 minute track of FLAC audio is around 30 million bytes, so it would take about 30 seconds to be sent over the network. The audio software does "one potato, two potato, three potato, four, five potato, six potato, seven potato, more,x of waiting for every one potato of work. Only DSD audio would be a challenge for a 10Mb network, but you probably have a 100Mb or 1Gb network.
In the end, what matters is whether it works. If you have dropouts, you have to start looking for the guilty. Otherwise, you need to enjoy the music.