There is no significant difference between Windows 10 Home and Windows 10 Pro that would be causing this issue.
There have, however, been many changes to Windows security, and one of them is probably causing the problem.
The first thing I would try is to download the installation file again, just in case there was an issue with the download up until now, then scan it with whatever security software you still have installed, and
then try the installation again.
If that fails, as you have uninstalled Webroot you should
uninstall the Malware protection software as well, as the next step. Make sure you reboot the PC after doing that, to ensure all components are removed. Check that nothing is left running of those two applications.
Then try the installation again. Disabling Microsoft Defender (that is what it is called these days) does not turn off all Windows Security components, or even completely stop Defender from working, I believe. Defender cannot be turned off fully via the GUI. It can only be done via Administration Policies. You will have to Google how to do that if you want to try.
If Microsoft Defender is the only security software installed now, you need to configure it as per the
Taming Windows Defender thread. Read that fully and decide how you want to do that, as it can be done in several ways. The discussion is worth reading before you implement it.
Microsoft Defender has many aspects now, not just Antivrus and Firewall. It could be that "App & Browser Control" is blocking the installation. Search in Windows for "Windows Security" and check all settings. I have that turned off as I use Norton Security products.
There may be other security components interfering. Make sure User Access Control (UAC) is set to the default level, or higher, so that you see notifications of changes to Windows when running the installer.
You also want other security components set to provide Notifications, or be in "Verbose Mode", so that Windows tells you when the installation is being blocked. I can't check as none of that is active with Norton installed.
Failing all that, open the Windows Event Viewer, try to run the installation, and see if any events are reported under Windows Logs. It could be in any of them, but likely in the Application, Security, or Setup logs.
See how you go.