I think the general consensus is to leave everything in RGB as that is the native color scheme for computers. Since the processing chain for video can involve multiple steps, the idea is that you want to avoid conversion between YCbCr<->RGB as there is the potential depending on what is doing the conversion to lose precision. It's like making successive copies of an analogue tape - every subsequent copy based on the last loses fidelity.
You have Windows, your video driver, Media Center, and your TV all involved in the chain to produce an image, and little insight (if any) at what exactly is taking place in the software as the video is processed along the way. So best bet - leave it RGB.
Far more knowledgeable people can weight in here, but I think this topic - if you do some searching both here in the forum and elsewhere - will show many discussions that will drive you crazy, and has been beaten to death over the years.
For me, I run RGB/10bpc at 4K resolution on my LG OLED. My video card is an nVidia 4090.
