I've had one for ages (got the photo the day they were released), had two iPods before this one.
I've had one technical problem with the iPod itself, which I resolved by having them give me a replacement. Otherwise all the other issues I've had have been with MC 11, but that's what I get for beta testing.
One thing to know is that MC cannot deal with photos on the iPod yet. So you need to still use iTunes for that. Many of us are doing that with no ill effects, but you want to make sure that iTunes and MC are not both open when you have the iPod connected. I don't sync any music using iTunes, just photos.
There are general rules are using iPods with MC, read those, they still apply. Other than that, it's not any different -- except bigger and more beautiful <g> -- than the other iPods.
BTW, as an aside, if you've not had an Mp3 player before, I would highly, highly recommend ditching the apple-supplied earbuds and buying some decent earphones. This will make a vast difference in your listening pleasure. Pretty much anything from $50 on up to $500 will be better than those apple ones.