I couldn't get iso's act like videos, but I have not spent too much time on this.
In general, sidecars for any selected file format would be a great feature for people who want to keep tags separate from data. This would allow us to do checksum on data and diff on tags.
For mp3's, I use mp3bookhelper, which can do checksum on mp3 data without looking at tags, but it is not maintained anymore and it works only for mp3s.