Windows Defender certainly shouldn't be an issue (and definitely not making it crash like that), and obviously this isn't a widespread problem.
A few things to check:
1. Does it crash immediately, or load and then crash?
2. Does the machine have an active network connection?
3. Any kind of software that might be blocking a network connection (firewall stuff or anything)?
4. Is there any log created here:
C:\Users\glynor\AppData\Roaming\J River\Media Center 19\Log.txt
5. Is there anything else you can think of funky about the machine or your install? Are you trying to run it as an admin (don't) or ran the Installer using a different account or as an admin, or anything else?
I don't think MC logs by default, though, so you might not have one if it is crashing on first-ever run and you can't even enable it. I might be able to get you a REG file you can import that will turn on logging and then we can look at a real log.
Also, so you know, crashes in module StackHash means that Windows was not able to determine what module caused the fault. This makes debugging the crash extremely difficult. This can often indicate hardware issues (often low memory or memory hardware faults, power supply issues), DEP related crashes (which shouldn't apply here), filesystem corruption, or malware activity. In this case, I can see it also indicating a GPU issue (though you'd be more likely to see that when entering Theater View or playing Video).
You might be able to work around it by disabling DEP for this application, though this ABSOLUTELY should not be required. It might let you run MC long enough to get us a good log, though.
And, unless you're absolutely positive the machine is rock-solid, it would be worth doing a Memtest 86+ check on it (using a known-clean CD/USB stick made on another computer) and at least one pass of Prime95, just to rule out basic hardware issues. Also, if you haven't done so, I'd do an chipset drivers update (from Intel, not Windows Update, assuming it is an Intel board/CPU).