While the 2i4 has two balanced outputs, I'm actually using the unbalanced rca outputs to connect to two power amplifiers. A rotel RB-990bx running a passive sub, and a cheap rack mount with identical sounding gain to the rotel running a pair of floor standing speakers. Interestingly the focusrite sounds about 3db quieter than the odac at the same internal volume level in jriver. I couldn't find any specs stating the gain of the rotel but a stereophile review of a similar amp the RB-991 measured a gain of 31.8dB so I guess it's the same or close to it.
The floor standers don't have a listed spec for sensitivity, I believe they're about 86dB, definitely no higher than 90dB.
I connected several different audio devices and listened for the hiss (a highly scientific process which involves my running around disconnecting a lot of cables and placing my ear against a speaker) which was inaudible or near enough to it on an asus xonar dx card, an iaudio7 mp3 player and the odac Even the noise floor of the onboard realtek audio device was only half as loud as the focusrite.
I found the focusrite's specs, the unbalanced outs should be outputting a +5.5 dBU signal which is about 3dB quieter than the ODAC's peak output, so you have a very good ear
. It looks like the Rotel is fully driven around 2dBU, so you have about 3dB of "excess input" on the Focusrite that you could try trimming with an attenuator (i.e. inputs over 2dBu may drive amp into clipping). But there's no reason that the unit (if functioning at it's rated electrical specs) should be giving that much noise compared to an asus dx or the ODAC
Before you send it back, I'd recommend trying it on some different USB ports; that recently cleared up a problem another user was having with his ODAC, oddly enough. Specifically, if it's on a USB 3 port, try plugging it in to a USB 2 port, or try plugging it into a powered USB hub. USB 3 ports give off some impressive interference; admittedly its in a band that shouldn't affect audio performance, but more than one forum user has had an issue that was resolved by changing USB ports, or moving a device to a hub.
I used to be pretty skeptical that changing USB ports could make a difference, until I read intel's white paper on USB 3 interference, and experienced it myself with a few devices (some audio, some not).