I get hangs too and have tried the same sorts of potential remedies i.e. turn off auto-import, deselect pictures and videos from importing, but it still happens. I don't have a Mac Keyboard, so I'm reluctant to keep playing music because if it hangs, I have to hard-kill my Mac by powering off with the power button at the back of the machine and so have resorted to playing discs until there's a more reliable fix.
Fwiw, it's happened with stereo and m/c FLAC and stereo and m/c SACD ISO files and on JR 20.64