Chiming in on this issue. I'm working on so many moving parts getting my server and MC and JRemote and my NAS up and configured that I haven't really worried about the intermittent dropouts until now, when I've actually had time to do a few extended listening sessions. I noticed dropouts and freezes in MC 19 and early versions of 20, but my setup was in constant flux so they might be red herrings; will focus on current setup (which will evolve again soon).
Server: Nov 2014 Mac mini 500GB SSD, 16GB RAM (headless; runs MC, Splashtop Streamer, Safari, WiFi, antivirus, period), Yosemite.
Media storage: Synology 1515+ NAS, direct-attached via Cat 7a ethernet (no hub, switch, or router) 5 x 5TB Seagate ent. class drives
External DAC: Oppo BDP-105D asynch USB DAC input, 0.7M Supra USB2.0 cable. No other USB devices connected.
I run this server headless; control the Mac with Splashtop and the Synology using Safari with DiskStationManager. Audio files are almost exclusively "single" DSFs. MC may stay on for several hours; Safari usually not, but sometimes. Never have multiple tabs open.
Relevant symptom is ~1 second dropouts, usually after some time (an hour or so) of play. May then get two or three within a few minutes, then often another hour or several before a repeat.
I'm not actively using the computer for anything but music and managing the NAS. I think I have most MC settings as recommended; I've played with integer and exclusive modes but can't attribute any effect on the occasional dropouts, likewise with memory play. Can test if desired.
I'll note one other symptom that may be entirely unrelated, but who knows: to bitstream DSD via asynch USB to the Oppo, I have to select it in the output device list in the System Prefs->Sound pane. I intermittently (but too often) lose all sound, very often just before the end of a playing track (noted in JRemote) with no action on my part, and also if I have to restart Splashtop or otherwise address the Mac. Turns out these are always cases where the Mac has released the Oppo device and switched to something called SoundFlower. This is more annoying and more frequent than the dropouts, but I experience both, and perhaps they're related.
Not to derail the thread, but does MC install and use this SoundFlower thing? If it's needed, is there some way to make sure the Mac stays defaulted to the Oppo once I set it? Can that setting be made persistent across reboots or set as a startup item in the user (admin) account? (Please move this to a new thread if appropriate).
I doubt I'm competent to assist in troubleshooting the dropout issue but wanted to report my setup and experience in case it's useful. MC is so powerful (and getting more so all the time) that it will be quite a while before I feel I can really drive this Ferrari with anything like skill or grace.
One final thought: in a month or so I expect to be acquiring an exaSound e22 DAC to replace the Oppo DAC. I know George has written custom Mac drivers; I don't know whether they supplement or substitute for any MC drivers. If the latter, do we know whether any MC users of those drivers are also experiencing the dropouts?
Thanks to everyone for all your hard work!