I use Comodo Internet Security. It's their new product which includes AV and Firewall. It's possible to install only the AV or the FW components (select during install).
Personally I love Comodo Internet Security because of its powerfull firewall. I used their firewall even before they had the "All In One Package". I only can say good things about the firewall. The Defense+ module also is VERY usefull, but often freezes protected programs for about 10 seconds.
Biggest problem with Comodo is, if it's not configured correctly, you get thousends of messages (especially from Defense+, but also from FW).
It's not easy to say something about the AV module, because it's difficult to test (for me). It has many false positives up to now, but they are working hard on that (I'm observing their forum) and I can say: for me IT IS getting better. But for me its still has more than eg. Avira AntiVirPE has.
If remember correct, there was a thread on their board round 10/2008, where one of the developer stated, that a detection rate comparable with other AV-products should be reached in one year -> 10/2009.