Which ever settings you are using, you should have Video Clock on. It smooths out small timing issues, which can stop the jumping, if timing is the cause of the problem.
Try both 6233638's recommendations ( "Display Settings automatic change mode" set to Auto with correct fps settings as above) and mine (run the TV in 1920x1080p 60Hz all the time and have MC convert to that format) and see if either work better.
When you are having problems with a file, check both your CPU and GPU loads. If any individual CPU core, or the GPU ever goes over 80% load, that could be your problem.
Check CPU load Windows Resource Monitor, accessible via the Windows Task Manager Performance tab.
Check GPU load using the "Sensors" tab in
GPU-Z, or your NVidia software if it has a better display.
Note that on my HTPC, upscaling from Standard Definition 720x576 @ 25fps interlaced PAL TV to 1080p @ 60fps isn't a problem.
However deinterlacing Australia's HD 1080i 1440x1080 @ 25fps interlaced PAL TV and running it at 25fps is a problem. From memory this caused one CPU core to run at 87% load and caused jumpiness. Strangely, upscaling the same source to 1080p isn't a problem for RO Standard.
So when you have a file that doesn't play well, check what is actually in it using
MediaInfo, and consider not just the fps, but the Bit Rate, whether it is interlaced, the original resolution, and the colour standard (PAL or NTSC). All can have different effects on CPU and GPU load.