Are we talking audio only?
In that case, for PCM sources (mp3, flac, etc) if you disable all DSP Studio tickboxes and set Volume Mode to Disabled Volume, your audio will remain untouched. MC will simply decode any encoded files and send untouched PCM to your DAC.
I can't think of other options that would touch audio if its setup like that.
For DSD sources, you need to enable bitstreaming under Tools/Audio and tick DSD or DoP.
If you wish to bitstream certain audiostreams from video sources as well you can tick them in the bitstream options as well along with DSD.
Things get a little bit more complex if you wish to bitstream audio but use DSP studio on videos. You'll need to setup different zones and enable automatic zone switching based on Media Type. If this is the case and you need help with that just ask.