For DSD native sample rates, you need to use the ASIO driver provided by IFI. You need to set DSD to bitstreaming in audio setup. Note that you cannot do volume leveling with native DSD. That is a limitation of the format. There is an option in bitstreaming DSD to convert higher sample rate DSD to PCM if the DAC does not handle the high sample rate.
If you use ASIO and then only set volume leveling in DSP Studio that will give you a very clean signal. Make sure none of the other DSP options are checked. Then volume leveling will be the only DSP used.
You can experiment with the Play from Memory options, but you probably will not hear any difference.
You do not have to do anything special with Windows 10. Some people will turn off Windows Defender looking at audio files, but, again, you probably will not hear any difference.