it is also worth while taking a look at all of the 'conversions' done in the path from data file to speakers.
Not just the d/a conversions, but any potential d/d conversions using multiple DACs, including DACs that may be running at different bit resolutions. Be sure to look at both hardware and software manipulations. Going through multiple 12, 14, 16, 18, and 24 bit conversions and then undergoing the final digital to analog conversion for the end user can play hell with digital media.
In a predominantly digital system (like an HTPC), you want the data path to remain the same (bit rate, resolution, etc) from the stored media file to the ultimate output/display device. Interconnects need to be digital, preferably optical. But if using optical cables adds mis-matching d/d or d/a conversions, look at, in order, digital coax or doing an early conversion to a pure analog processing path.
In a higher-end mixed analog/digital system, you want to make the d/a conversion once, and as close to the playback device as possible. Again, the use of quality, matching analog interconnects (bandwidth, capacitance, resistance, EMI resistance, etc) is just as important as working to maintain the integrity of a digital signal path.
Don't ignore the internal interconnects of your components. If a mid-range receiver/amplifier uses internal components (even something as innocent looking as too-narrow copper PCB traces to move signals from pre-amp to amp sections) that muddy up a digital or analog signal, get rid of it. If a media player or digital distribution system shoves bits through multiple conversions for no good reason, look closely at cleaning up that mess.
So draw out a block diagram of your media system from the storage/playback device all the way to the speakers and displays. Leave enough room to document the software, hardware, d/a & d/d conversions, and type/bandwidth of interconnects. Starting with this document, you will be able to identify the sources of distortion and/or interference and then work to correct them OR rework your system to fix things up.
DO NOT start out with trendy fixes like power filters, 'pure' oxygen-free copper cables, name-brand audio-feely black boxes and crap like that. Get your system DOCUMENTED and then work out an improvement plan. Once that is in hand you can start to apply effort and $$ (or $$$$$) to work things out.