I added the Defender exceptions for both executable and data folders for MC. Still had the issue. I then added the 3 media folders and the issue went away. The media center has ran all afternoon and all night. Still has not crashed MC. I believe this fixed it.
It is helpful to get such a clear cut Defender issue and a solution. So, could you try one thing as an experiment. It would be appreciated, if you have the time.
The Microsoft documentation says that if you do the exceptions in a certain way for the Program Files/J RIver folder, then you do not have to do exceptions for the media folders. That happens automatically. Your case seems to be a way to check if that is really true.
Remove the media folder exceptions. And add a Folder exception for Program Files\J River and and Process exception for Program Files\J River\*. The Folder and Process options come up when you hit Add An Exclusion. According to Microsoft documentation doing a folder exception and an process exception should exclude the program and its files, as well as all the files that the programs open. It is not clear if the \* is necessary for the Process exception, but Microsoft includes it.
That would be a good test of something that is just theoretical at this time, based on somewhat sketchy Microsoft documentation.
Hope you have the time. Thanks.