Well, here goes:
I've received the Harmony 1100 yesterday and played arround with it for about 2 hours. Configuring and testing is a bit tedious because you can's use the device when it is hooked up to via USB. So you'll have to set it up, unhook, test it and hook it up again after testing to be able to make changes.
Setting it up is very easy though. The wizards are pretty smart and help you through the process quite fluently. All my devices were recognized without any problems (although the Amplifier's remote control has a 'video' selection it did not show up in the wizard, haven't solved that one yet).
One of the devices is my Mac Mini. In the Logitech DB this device was found and added accordingly. Since I had installed the Apple drivers, which are on the OS DVD delivered with the Mac, somehow MC13 was able to receive commands from the remote immediately (IRMan?).
Fazit: In 2 hours I was able to set up all the devices (except for the 'video' thingy) and have them work together flawlessly. Even my Mac Mini works like a charm with de default settings. The bigger challenge now is going to be to customize the remote to my liking, but first impression is super.
Cheers,
Paul